Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis (NANO-LM)

University of Zurich (UZH)

Status: Enrolling

Conditions: Leptomeningeal Cancer; Leptomeningeal Metastasis; Leptomeningeal Disease; Leptomeningeal Neoplasms

Treatments: Other: Neurological Assessment

Study type: Observational

Funder types: Other

Identifiers

NCT06417710

NANO-LM-01

Details and patient eligibility

About

The goal of this project is to develop and validate a reproducible scorecard for the neurological assessment of patients with leptomeningeal metastases that can be used in clinical trials including such patients, as well as in clinical practice.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients (18 years or more), female or male
• Histologically confirmed diagnosis of extra-CNS primary solid cancer
• Diagnosis of leptomeningeal metastases confirmed or probable per EANO ESMO criteria
• Performance status compatible with enrolment into clinical trials
• Ability to consent
• Signed informed consent form from patient
• Participation in a parallel clinical trial is allowed in this non-interventional study

Exclusion criteria

• Inability to give informed consent
• Inability to adhere to recommended follow-up according to the treating physician

Vulnerable participants will not be included.