Standardized Diagnosis and Treatment of Endocrine Hypertension

Affiliated Hospital of Nantong University

Status: Enrolling

Conditions: Endocrine Hypertension

Treatments: Procedure: Standardized diagnosis and treatment

Study type: Observational

Funder types: Other

Identifiers

NCT05149781

1

Details and patient eligibility

About

Cases of endocrine hypertension or primary hypertension who have signed informed consent will be collected. Patients with endocrine hypertension will be divided into surgical treatment group and drug treatment group according to actual treatment situation. A database will be established for all patients. The investigators will comprehensively evaluate the general conditions, past medical history, metabolic and biochemical indicators, psychological status, cardiovascular risk factors. All the patients will be followed up for 12 months at baseline, 6 months and 12 months. Clinical data and specimen will be collected.

Full description

The investigators will collect 100 patients with secretory hypertension and 100 patients with essential hypertension. Patients with endocrine hypertension will be divided into surgical treatment group and drug treatment group according to actual treatment situation. Resected specimens from surgical patients will be used for immunohistochemistry and western blot. A database will be established for all patients to assess their general situation, past medical history, metabolic and biochemical indicators, psychological status, cardiovascular risk factors, etc. The investigators expect to find more accurate screening indicators from blood and urine specimens. All the patients will be followed up for 12 months at baseline, 6 months and 12 months. Blood pressure, degree of atherosclerosis, biochemical markers, hormone levels and cardiac function indicators will be measured at three time points.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

age≥18 years

Exclusion criteria

1. myocardial infarction
2. congestive heart failure
3. stroke

Trial design

200 participants in 2 patient groups

patients with EH

Description:

patients with endocrine hypertension

Treatment:

Procedure: Standardized diagnosis and treatment

patients with PH

Description:

patients with primary hypertension