Standing Cognition and Co-morbidities of POTS Evaluation (SCOPE)

Penn State Health

Status: Completed

Conditions: Ehlers-Danlos Syndrome; Postural Tachycardia Syndrome

Treatments: Behavioral: Supine; Behavioral: Standing

Study type: Interventional

Funder types: Other

Identifiers

NCT03602482

Study00009606

Details and patient eligibility

About

The purpose of this study is to evaluate cognition in patients with postural tachycardia syndrome (POTS) while lying down and standing and to assess the prevalence of hypermobile Ehlers-Danlos Syndrome in POTS.

Enrollment: 139 patients

Sex: All

Ages: 13 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Previously diagnosed with POTS, or healthy control
• Age between 13-60 years
• Participants may be any race, ethnicity, sex, or gender
• Able and willing to provide informed consent

Exclusion criteria

• Inability to give, or withdrawal of, informed consent
• Age ≤ 13 or ≥ 61 years
• Prisoners
• Unable to stand

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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139 participants in 2 patient groups

Standing

Experimental group

Description:

Participants will complete cognitive testing while standing.

Treatment:

Behavioral: Standing

Supine

Active Comparator group

Description:

Participants will complete cognitive testing while supine.

Treatment:

Behavioral: Supine