Staphylokinase and ABO Group Phenotype: New Players in Staphylococcus Aureus Implant-associated Infections Development

Nantes University Hospital (NUH)

Status: Completed

Conditions: Staphylococcal Infection

Treatments: Other: IAI infection; Other: Staphylococcus aureus nasal carriage infection

Study type: Observational

Funder types: Other

Identifiers

NCT02812446

RC15_0456

Details and patient eligibility

About

The purpose of this study is to identify bacterial and/or clinical features involved in the pathogenesis of Staphylococcus aureus implant-associated infections (IAI). Materials & methods: In total, 57 IAI S. aureus and 31 nasal carriage (NC) S. aureus isolates were studied. Staphylococcus aureus genetic background was obtained by microarray analysis. Multilocus sequence typing was performed to determine clonal complexes (CC). Biofilm production was investigated by resazurin and crystal violet methods

Enrollment: 88 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• infected patients with S. Aureus IAI infection
• noninfected patients screened for S. aureus nasal colonization at the orthopedic consultation ward

Exclusion criteria

• minor

Trial design

88 participants in 2 patient groups

IAI patients group

Description:

patients with Staphylococcus aureus of implant-associated infections

Treatment:

Other: IAI infection

control group

Description:

patients with Staphylococcus aureus nasal carriage

Treatment:

Other: Staphylococcus aureus nasal carriage infection