Statistical Learning as a Novel Intervention for Cortical Blindness

University of Rochester

Status

Invitation-only

Conditions

Hemianopsia

Visual Field Defect, Peripheral

Hemianopia, Homonymous

Stroke Hemorrhagic

Vision Loss Partial

Quadrantanopia

Stroke, Ischemic

Occipital Lobe Infarct

Treatments

Device: Vision Training and Learning Task

Study type

Interventional

Funder types

Other

Identifiers

NCT06578117

STUDY00009495

Details and patient eligibility

About

This project aims to develop a novel visual training paradigm for use in visually-intact participants and those sufferings from stroke-induced visual impairments. Our task design is built upon theories of statistical learning to reduce the overall training burden while still producing profound improvements to visual abilities. Efficacy will be first established in visually-intact controls before testing in stroke survivors to assess the feasibility of this form of learning in the damaged visual system.

Enrollment

30 estimated patients

Sex

All

Ages

21 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Cortically Blind participants

Inclusion criteria:

Between 21 and 75 years of age
Residents of the United States or Canada
Have successfully completed previous enrollment in Dr. Huxlin study (IRB #5966 or #75)
Exhibit unilateral stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range of 21 - 75 years (verified by MRI and/or CT scans)
Reliable visual field defects in both eyes (homonymous defects) as measured by Humphrey visual fields. This deficit must be large enough to enclose a 5-deg diameter visual stimulus.
Able to fixate on visual targets reliably for 1000ms within 1-deg of visual angle.
Willing, able, and competent to provide their own informed consent
Normal cognitive abilities and be able to understand written and oral instructions in English

Exclusion criteria:

Past or present ocular disease interfering with visual acuity
Best corrected visual acuity (BCVA) worse than 20/40 in either eye
Sustained documented or suspected damage to the dorsal Lateral Geniculate Nucleus
Presence of diffuse whole brain degenerative processes
History of traumatic brain injury
Any other brain damage deemed by study staff to potentially interfere with training ability or outcome measures
Documented history of drug/alcohol abuse
Currently taking neuroactive medications which would impact training, as determined by PI
Cognitive or seizure disorders
One-sided attentional neglect
Those who lack the competence or are otherwise unable to perform the visual training exercises as directed.

Control participants

Inclusion criteria:

Between 21 and 75 years of age
No history of neurological disorder.
Competent and responsible, as determined by the screening interview

Exclusion criteria:

Any damage to the visual system
Those who are suffering from an active disease process involving their nervous system.
Presence of cognitive or seizure disorders
Best corrected visual acuity worse than 20/40 in either eye
Presence of visual field loss from ocular disease or disorder