Status Asthmaticus on the Intensive Care Prospective - STATIC PRO

Erasmus University

Status: Completed

Conditions: Childhood Asthma With Status Asthmaticus

Study type: Observational

Funder types: Other

Identifiers

NCT02936778

NL52508.078.15

Details and patient eligibility

About

This study will prospectively assess the impact and relevance of several risk factors for children with severe acute asthma (SAA) or acute wheeze that have been identified in retrospective studies. Secondary we will assess short-term medical and psychosocial functioning in patient (and parents) admitted to a PICU for SAA/acute wheeze versus a control group admitted to a MC for SAA/acute wheeze.

Enrollment: 221 patients

Sex: All

Ages: 2 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Between 2 and 18 years of age
• Admission to a PICU for SAA or acute wheeze or admission to a MC for SAA or acute wheeze

Exclusion criteria

• Patient is outside of specified age range
• Down's Syndrome
• Congenital/acquired heart defect that interferes with normal SAA treatment
• Congenital/acquired airway defect (tracheomalacia/bronchomalacia)
• Primary/secondary immunodeficiency
• Pre-existing chronic pulmonary condition, known to mimic asthma: Cystic Fibrosis, Bronchopulmonary dysplasia, Bronchiolitis obliterans
• If both parents are not able to speak the Dutch language

Trial design

221 participants in 2 patient groups

PICU (= case group)

Description:

Children aged 2-18 years admitted to a Paediatric Intensive Care Unit in the Netherlands, with a diagnosis of acute wheeze or SAA.

MC (= control group)

Description:

Children aged 2-18 years admitted to a Medium Care in the Netherlands, with a diagnosis of acute wheeze or SAA.