Stellate Block Versus Nimodipine Infusion for Traumatic Brain Injury

Sohag University

Status and phase: Unknown; Early Phase 1

Conditions: Traumatic Brain Injury

Treatments: Procedure: ultrasound-guided stellate ganglion block

Study type: Interventional

Funder types: Other

Identifiers

NCT05182619

soh-Med-21-12-19

Details and patient eligibility

About

the study is designed to perform an intervention for enhancement of cerebral blood flow in patients with traumatic brain injury showing vasospasm through transcranial doppler

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients more than 18 ys old with isolated head trauma and traumatic brain injury

Exclusion criteria

• • Hemodynamic instability (mean ABP less than 70 mmHg)

  • History of severe systemic disease including cardiopulmonary failure or hepatorenal failure
  • Allergy to local anesthetics
  • Coagulation disorders
  • Abnormal neck structures disturbing normal anatomy as neck tumors

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

ultrasoung guided stellate block

Active Comparator group

Description:

stellate ganglion will have ultrasound-guided block via bupivacaine for sympathectomy and enhancement of cerebral blood flow

Treatment:

Procedure: ultrasound-guided stellate ganglion block

nimodipine infusion

Active Comparator group

Description:

intravenous nimodipine will be given for enhancement of cerebral blood flow

Treatment:

Procedure: ultrasound-guided stellate ganglion block