Stem Cell Research on Subjects at Genetic High Risk for Schizophrenia

Seoul National University

Status: Completed

Conditions: Genetic High Risk for Schizophrenia

Study type: Observational

Funder types: Other

Identifiers

NCT01943175

A120476 (Other Grant/Funding Number)

H-1207-117-419

Details and patient eligibility

About

This study aims at finding endophenotypes of schizophrenia at neuronal level by obtaining stem cells which is derived from adipose cells of subjects with heavy genetic loading for schizophrenia then differentiating them into neuronal cells.

Enrollment: 24 patients

Sex: All

Ages: 20 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

[Subjects at genetic high risk for schizophrenia]

• Healthy without any Axis I mental disorder
• Is a monozygotic twin of a patient with schizophrenia OR Has at least two family members of schizophrenia in the pedigree, including at least one 1st-degree family member

[Healthy Control]

• Healthy without any Axis I mental disorder
• No family members of schizophrenia in the pedigree to the 3rd degree

Exclusion criteria

• Significant neurological or medical illness
• Psychotic symptoms
• Substance abuse
• Suicidal risk
• Blindness or hearing loss
• Taking aspirin, warfarin or hormonal agents
• Pregnancy or lactation
• Susceptibility for keloid formation
• Allergy to lidocaine
• History of significant head trauma or loss of consciousness
• Mental retardation

Trial design

24 participants in 2 patient groups

Genetic High Risk

Healthy Control