Stem Cell Transplant From Matched Unrelated or Partially Matched Related Donors

Stanford University

Status: Completed

Conditions: Blood Cancer; Blood and Marrow Transplant (BMT)

Treatments: Procedure: ablative allogeneic hematopoietic cell transplantation

Study type: Interventional

Funder types: Other

Identifiers

NCT00186225

75268 (Other Identifier)

IRB-13390

BMT22 (Other Identifier)

Details and patient eligibility

About

To evaluate the use of unrelated donors for hematopoietic cell transplantation in the treatment of hematologic and lymphoid malignancies.

Full description

Stem Cell Transplantation from Matched Unrelated or Partially Matched Related Donors Using a Preparatory Regimen Consisting of Fractionated Total Body Irradiation (FTBI) and Cyclophosphamide (CY). To administer high dose radio-chemotherapy followed by stem cell transplantation from a matched unrelated donor or a partially matched related donor.

Enrollment: 250 estimated patients

Sex: All

Ages: 4 weeks to 50 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:- acute leukemia

• chronic leukemia
• lymphoblastic lymphoma
• MDS
• MPS Exclusion Criteria:- organ dysfunction
• HIV positive

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)