Stem Cell Transplantation In-patient With Neurological Sequelae Due to Encephalitis or Meningitis

Vinmec Research Institute of Stem Cell and Gene Technology

Status and phase: Completed; Phase 2; Phase 1

Conditions: Meningitis; Encephalitis

Treatments: Combination Product: Stem cell transplantation

Study type: Interventional

Funder types: Other

Identifiers

NCT04080921

CS. ĐT.19H2

Details and patient eligibility

About

To evaluate the safety and efficacy of autologous bone marrow-derived mononuclear cell transplantation in-patient with neurological sequelae due to encephalitis or meningitis

Full description

The purpose of this study is to evaluate the safety and effectiveness of autologous bone marrow-derived mononuclear cell in 22 patients with neurological sequelae due to encephalitis or meningitis at Vinmec International Hospital, Hanoi, Vietnam

Enrollment: 22 patients

Sex: All

Ages: 2 to 15 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Neurological sequelae due to encephalitis or meningitis

Exclusion criteria

• Coagulation disorders
• Allergy to anesthetic agents
• Severe health conditions such as cancer, failure of heart, lung, liver or kidney
• Active infections

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

22 participants in 1 patient group

Stem cell transplantation

Experimental group

Description:

Stem cell transplantation 2 intrathecal administrations of autologous bone marrow mononuclear cells at baseline and 6 months afterward

Treatment:

Combination Product: Stem cell transplantation