Stem Cells for Bronchopulmonary Dysplasia

Army Medical University of People's Liberation Army

Status and phase: Withdrawn; Early Phase 1

Conditions: Bronchopulmonary Dysplasia

Treatments: Drug: transplantation of mesenchymal stem cell; Drug: no transplantation of mesenchymal stem cell

Study type: Interventional

Funder types: Other

Identifiers

NCT03378063

stem cell for BPD

Details and patient eligibility

About

Very preterm infants are at high risk to develop to bronchopulmonary dysplasia (BPD) for the lack of effective measures to prevent or ameliorate this common and serious disorder. BPD remains a major cause of mortality and lifelong morbidity in preterm infants

Full description

Several studies have shown that transplantation of mesenchymal stem cells (MSCs) in immunocompetent animals attenuates lung injury, such as impaired alveolarization, inflammatory response, increased apoptosis, and fibrosis. Human umbilical cord blood (hUCB) is considered a better source of MSCs because of their ready availability and greater proliferative capacity and less antigenicity than other cell types.

transplantation of hUCB-derived MSCs should be effective in treating BPD. The safety and efficacy of MSC transplantation for prevention of BPD has not been tested previously, however.

Sex: All

Ages: 1 to 3 months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosed with BPD

Exclusion criteria

• parents' rejection

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

transplantation of mesenchymal stem cell

Experimental group

Description:

transplantation of mesenchymal stem cell will be given to the infants with BPD.

Treatment:

Drug: transplantation of mesenchymal stem cell

no transplantation of mesenchymal stem cell

Active Comparator group

Description:

transplantation of mesenchymal stem cell will be not given to the infants with BPD.

Treatment:

Drug: no transplantation of mesenchymal stem cell