Stem Cells for Treatment of Bronchopleural Fistula

The Second Affiliated Hospital of Fujian Medical University

Status and phase: Unknown; Phase 1

Conditions: Bronchopleural Fistula

Treatments: Biological: UCMSC

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02961725

SC-BF

Details and patient eligibility

About

Bronchopleural fistula (BF), an abnormal passage or communication between a bronchus and another part of the body, may develop when there are penetrating wounds of the thorax and after lung surgery. Without effective therapy, treatment of BF is a challenge, with a high rate of mortality and teratogenicity.

The investigators will conduct endoscopic injection of umbilical cord mesenchymal stem cells to fistula, observe the recovery of bronchopleural fistula and systemic reactions, to investigate the application of umbilical cord mesenchymal stem cells in the treatment of bronchopleural fistula.

Enrollment: 10 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosed with bronchopleural fistula by imaging or bronchoscopic examination
• typical symptom of bronchopleural fistula, such as fever, cough, purulent sputum, weight loss...
• patients present compromised conditions, who can only accept a conservative treatment.

Exclusion criteria

• absolute contraindication of bronchoscopic examination and treatment
• with previous treatment of cell therapy, including stem cells.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

UCMSC treatment

Experimental group

Description:

UCMSC: umbilical cord mesenchymal stem cells

Treatment:

Biological: UCMSC