Stem Cells Therapy in Advanced Heart Failure

University of Campania "Luigi Vanvitelli"

Status and phase: Unknown; Phase 4

Conditions: Congestive Heart Failure

Treatments: Drug: stem cells infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT02871466

8.2016

Details and patient eligibility

About

stem cells therapy may be a choice therapy for advanced heart failure patients refractory to medical therapy, internal cardiovertor with a defibrillator (ICD) recipients, and a previous history of myocardial infarction and coronary artery revascularization. These patients, without indication to receive a cardiac resynchronization therapy (CRT), may have a worsening of heart failure, and symptoms of coronary artery disease. In this study we have evaluated in consecutive 30 selected patients the amelioration in failing heart NYHA class, hospitalization rate, echocardiographic left ventricle functionality, and associated to reduction of angina after a treatment with stem cells intra thoracic infusion.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• heart failure post coronary artery disease, refractory to maximal medical therapy, previous coronary artery surgical revascularization.

Exclusion criteria

• inflammatory chronic diseases, neoplastic diseases.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

stem cells infusion

Experimental group

Treatment:

Drug: stem cells infusion