Stent Placement and the Risk of New-onset AF in Patients With AMI

Mackay Memorial Hospital

Status: Unknown

Conditions: Atrial Fibrillation New Onset; Acute Myocardial Infarction

Treatments: Device: DES or BMS

Study type: Observational

Funder types: Other

Identifiers

NCT03382990

Stent-AF Trial

Details and patient eligibility

About

The benefit of a drug-eluting stent (DES) in patients with acute myocardial infarction (AMI) is controversial. This study will aim to observe the effect of a DES on the risk of new-onset AF in patients with AMI.

Full description

Acute myocardial infarction (AMI) is the leading cause of mortality in the world. Early invasive strategy with percutaneous coronary intervention (PCI) has been demonstrated to be the most effective strategy to treat AMI. Although drug-eluting stent (DES) has not shown benefits to reduce mortality rate among AMI patients compared with bare-metal stent (BMS), the use of DES in real-world is increasing because of reduced restenosis rates. AMI patients are at higher risk to develop atrial fibrillation (AF) than general population. However, whether early PCI with DES implantation is related to a reduced risk of AF still remains unclear. The purpose of this study is to investigate the association of DES implantation and the risk of AF among patients with AMI treated by early PCI.

Enrollment: 40,000 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients were enrolled by primary diagnostic coding as acute myocardial infarction and treatment coding as receiving PCI between 2007 and 2013 in Taiwan National Health Insurance Research Database (NHIRD)

Exclusion criteria

1. Less than 20-years-old; Unknown sex and age
2. Not residents in Taiwan
3. Died during AMI admission
4. Previous history of AF
5. Receiving coronary artery bypass grafting (CABG), ventricular assist device (VAD), extracorporeal membrane oxygenation (ECMO), and heart transplantation during observational and/or database period
6. No stent implantation during PCI
7. Unknown stent types

Trial design

40,000 participants in 2 patient groups

STEMI

Description:

Patients with STEMI treated with PCI and stent placement (DES or BMS)

Treatment:

Device: DES or BMS

NSTEMI

Description:

Patients with NSTEMI treated with PCI and stent placement (DES or BMS)

Treatment:

Device: DES or BMS