Stereotactic Radiosurgery and Erlotinib in Treating Patients With Non-Small Cell Lung Cancer and Brain Metastases

University of California San Francisco (UCSF)

Status and phase

Withdrawn

Phase 1

Conditions

Metastatic Cancer

Lung Cancer

Treatments

Other: laboratory biomarker analysis

Other: pharmacological study

Radiation: stereotactic radiosurgery

Other: liquid chromatography

Other: mass spectrometry

Drug: erlotinib hydrochloride

Other: immunoenzyme technique

Study type

Interventional

Funder types

Other

Identifiers

NCT00738335

CC# 072520

UCSF-072520

GENENTECH-UCSF-072520

CDR0000612064

Details and patient eligibility

About

RATIONALE: Erlotinib may stop the growth of tumor cells by blocking the enzymes necessary for their growth. Radiation therapy uses high-energy x-rays to kill tumor cells. Stereotactic radiosurgery may be able to deliver x-rays directly to the tumor and cause less damage to normal tissue. Erlotinib may make tumor cells more sensitive to radiation therapy. Giving erlotinib together with stereotactic radiosurgery may kill more tumor cells.

PURPOSE: This phase I clinical trial is studying the side effects of erlotinib when given together with stereotactic radiosurgery and to see how well it works in treating patients with non-small cell lung cancer with brain metastases.

Full description

OBJECTIVES:

Primary

To determine the acute as well as long-term toxicity (especially grade III neurotoxicity) of concurrent erlotinib hydrochloride and single-fraction radiosurgery in patients with non-small cell lung cancer (NSCLC) and brain metastases.

Secondary

To determine the freedom from progression in all detected lesions (i.e., radiosurgically treated and untreated) and the rate of response of radiosurgically treated lesions in patients receiving concurrent erlotinib hydrochloride and radiosurgery as compared with historical controls treated with gamma knife radiosurgery alone at UCSF.
To measure the rate of freedom from any CNS progression in these patients at 1 year post treatment.
To assess cerebrospinal fluid (CSF) distribution of erlotinib hydrochloride by measuring both erlotinib hydrochloride and its major metabolite, OSI-420, in plasma and CSF at 4 or more days after initial erlotinib hydrochloride administration but before radiosurgery, and again at 4 weeks after stereotactic radiosurgery (optional).
To perform CSF and serum biomarker analysis for NSCLC using 2-dimensional liquid chromatography or mass spectrometry (2D-LC/MS).
To determine the incidence of subclinical leptomeningeal disease in patients assigned to gamma-knife treatment and who do not exhibit signs or symptoms or carcinomatous meningitis.

OUTLINE: Patients receive oral erlotinib hydrochloride once daily for at least 7 days. Patients then undergo stereotactic radiosurgery on day 0. Beginning the day after radiosurgery, patients receive erlotinib hydrochloride once daily for 4 weeks in the absence of disease progression or unacceptable toxicity. After completion of study therapy, patients may continue to receive erlotinib hydrochloride at the discretion of their oncologist.

Patients undergo cerebrospinal fluid (CSF) and blood sample collection at baseline (at least 4 days after starting erlotinib hydrochloride and prior to radiosurgery) for pharmacokinetic and biomarker correlative studies. Samples are analyzed for concentrations of erlotinib hydrochloride by 2-dimensional-liquid chromatography/mass spectrometry and antithrombin by enzyme-linked immunosorbent assay.

After completion of study therapy, patients are followed every 3 months for 1 year.

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

Histologically confirmed non-small cell lung cancer (NSCLC) meeting the following criteria:
- Fewer than 5 intraparenchymal brain metastases by gadolinium-enhanced MRI meeting the following criteria:
  - Maximum diameter ≤ 4.0 cm
    - If multiple lesions are present and one lesion is > 3.0 cm, the remaining lesions must be ≤ 3.0 cm in maximum diameter
  - No metastases within 3 mm of the optic nerve or optic chiasm such that some portion of the optic nerve or chiasm would receive > 9 Gy from radiosurgery
  - No metastases in the brainstem, midbrain, pons, or medulla
No prior complete resection of a single brain metastasis or of all known brain metastases
- Subtotal resection allowed provided residual disease is ≤ 4.0 cm in maximum diameter
No clinical or radiographic evidence of unstable systemic progression (other than the study lesion[s]) within the past month
- Patients with brain metastases at initial presentation do not require 1 month of scans documenting stable disease
Isolated brain metastases with stable systemic disease allowed
No leptomeningeal metastases by MRI and/or positive cerebrospinal fluid cytology

PATIENT CHARACTERISTICS:

Karnofsky performance status 60-100%
Life expectancy ≥ 3 months
ANC > 1,000/mm³
Platelet count > 100,000/mm³
Hemoglobin > 10 g/dL
PT and PTT normal
AST < 2 times upper limit of normal (ULN)
Alkaline phosphatase < 2 times ULN
Total bilirubin < 2 times ULN
Lactic dehydrogenase < 2 times ULN
Serum creatinine < 1.5 times ULN
Not pregnant or nursing
Negative pregnancy test
Fertile patients must use effective contraception during and for ≥ 2 weeks after completion of study therapy
Neurologic function status 0-2
No history of allergic reactions attributed to compounds of similar chemical or biologic composition to erlotinib hydrochloride
No contraindication to MRI (e.g., cardiac pacemaker)
No absolute contraindication to lumbar puncture

PRIOR CONCURRENT THERAPY:

See Disease Characteristics
Prior systemic therapy allowed
No prior cranial radiotherapy
- Prior radiotherapy to noncranial sites allowed
More than 1 week since prior intrathecal chemotherapy or prior treatment of leptomeningeal carcinoma
No concurrent systemic therapy
- Prior or current erlotinib hydrochloride for treatment of systemic disease allowed provided systemic disease has not progressed while on erlotinib hydrochloride
No concurrent enzyme-inducing anticonvulsant
- If patients are on an enzyme-inducing anticonvulsant (e.g., phenytoin, carbamazepine, or phenobarbital), the agent must be converted to a nonenzyme-inducing anticonvulsant before or at the start of erlotinib hydrochloride treatment
No concurrent CYP3A4 inhibitors or inducers (e.g., Hypericum perforatum [St. John wort] or ketoconazole)
No other concurrent investigational therapy