Steroids After Laser Trabeculoplasty for Glaucoma (SALT)

Stanford University

Status and phase: Completed; Phase 4

Conditions: Glaucoma

Treatments: Drug: Ketorolac; Drug: Artificial Tears; Drug: Prednisolone 1%

Study type: Interventional

Funder types: Other

Identifiers

NCT00981435

20081142

Details and patient eligibility

About

The purpose of this study is to determine whether the choice of post-operative eye drop administered after selective laser trabeculoplasty (SLT) for glaucoma affects the efficacy in lowering intraocular pressure (IOP).

Full description

SLT is used to lower intraocular pressure in glaucoma, but it is not know whether the choice of eyedrops administered in the post-operative period affects SLT efficacy. Practitioners commonly use steroid drops, non-steroidal anti-inflammatory drops, or no drops at all. This is a randomized, single-center, prospective, masked clinical trial to determine whether the choice of eyedrop affects efficacy of SLT in glaucoma patients.

Enrollment: 97 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical diagnosis of glaucoma
• clinician has determined that SLT laser is indicated
• IOP currently >18 and was ever >21 in the past (e.g. prior to treatment)

Exclusion criteria

• prior history of uveitis
• prior glaucoma surgery including glaucoma laser surgery
• pregnant or 3 months post-partum

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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97 participants in 3 patient groups

Artificial Tears

Experimental group

Description:

Topical artificial tears dosed 4 times per day for 4 days in treated eye after laser trabeculoplasty.

Treatment:

Drug: Artificial Tears

Non-steroidal anti-inflammatory

Experimental group

Description:

Topical ketorolac 0.5% dosed 4 times per day for 4 days in treated eye after laser trabeculoplasty.

Treatment:

Drug: Ketorolac

Steroid

Experimental group

Description:

Topical prednisolone 1% dosed 4 times per day for 4 days in treated eye after laser trabeculoplasty.

Treatment:

Drug: Prednisolone 1%