Stevia Extract and Glucose Homeostasis

Liverpool Hope University

Status: Withdrawn

Conditions: Overweight; Obesity

Treatments: Other: sugar replacements

Study type: Interventional

Funder types: Other

Identifiers

NCT04335565

13022020

Details and patient eligibility

About

This study aims to assess the effect of stevia extract on postprandial glucose and insulin levels in overweight and obese adults when compared to sugar and water.

Full description

The study is a three-arm crossover trial involving participants attending the Lab on 3 different occasions (separated by 3-5 day washout period), where they will be administered water, sugar solution (65g), water and stevia extract (5g) solution. The solution will be followed by a consumption of a fixed meal (after 30 minutes). Breakfast will be standardised. Capillary blood glucose will be collected every 30 min until 2 hours post meal. Venous blood samples will be collected before the intake of the solution and at 2 hours after meal intake.

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-65 years
• BMI 27-40 Kg/m2
• Males and females

Exclusion criteria

• Athletes
• Pregnant or breastfeeding women
• Patients with chronic disease (diabetes, CVD etc...).

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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0 participants in 3 patient groups

Water

No Intervention group

Description:

250 ml of water mixed with 1g of citric acid.

Sugar

Active Comparator group

Description:

65g of sugar dissolved in 250ml of water

Treatment:

Other: sugar replacements

Stevia

Experimental group

Description:

5g of stevia dissolved in 250ml of water

Treatment:

Other: sugar replacements