Stevia Rebaudiana Bertoni on Levels of GCF Glucose and Bio-markers in Diabetics.

SVS Institute of Dental Sciences

Status and phase: Unknown; Phase 2

Conditions: Periodontitis

Treatments: Other: placebo; Drug: stevia rebaudiana bertoni

Study type: Interventional

Funder types: Other

Identifiers

NCT04381598

SVSIDS/perio/3/2019

Details and patient eligibility

About

With the increase in the incidence of diabetes and obesity, among other artificial sweeteners the need of natural non-caloric sweetener with acceptable taste and without any adverse effects is demanding.So,the use of stevia presents beneficial effects to general and oral health and its properties could result potentially effective in the treatment of periodontal diseases.

Full description

Stevia is considered as a novel molecule, because it is 100% natural and non caloric sweetener, with more sweetness than sucrose, without any adverse effects. It also demonstrates multiple benefits like anti-plaque effect, anti-diabetic effect, anti-periodontophatics properties, anti-hypertensive properties, anti-cariogenic properties etc. There are many studies conducted on stevia in humans, which justifies my study.

Enrollment: 19 estimated patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects that will be included in the study are in the age group ranging from 20-70 years -with established diabetes and under medication to maintain normal glycemic state i.e;Hb1Ac < 7％.
• Oral findings including the presence of minimum of 16 natural teeth with minimum of 4 nonadjacent sites showing pocket depths≥ 5 mm.

Exclusion criteria

Subjects will be excluded from the study if they are using

• any type of mouth-rinses or if they had underwent any periodontal therapy within the 3-months of the study or
• if they were under antibiotics within the 3-months of the study.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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19 participants in 2 patient groups, including a placebo group

stevia rebaudiana bertoni

Experimental group

Description:

Randomly in all subjects one quadrant will be allotted as test site for placing stevia gel in the gingival sulcus having probing depth ≥ 5mm after performing thorough scaling and root planing.

Treatment:

Drug: stevia rebaudiana bertoni

placebo

Placebo Comparator group

Description:

Other quadrant will be allotted as a control site for placing placebo in the gingival sulcus having PD≥ 5mm after performing thorough scaling and root planing.

Treatment:

Other: placebo