STI571 ProspectIve RandomIzed Trial: SPIRIT

Poitiers University Hospital

Status and phase: Completed; Phase 3

Conditions: Chronic Myeloid Leukemia

Treatments: Drug: Imatinib 400 mg + Peg-Interferon; Drug: Imatinib mesylate 400 mg + Cytarabine; Drug: Imatinib mesylate 600 mg; Drug: Imatinib mesylate 400 mg

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00219739

SPIRIT

Details and patient eligibility

About

To test whether increasing the dose of imatinib or combining it with IFNalpha or ara-C increases the rate of molecular response (as measured by the decrease in BCR-ABL transcripts after 12 months of treatment) in patients with previously untreated CML in chronic phase.

To compare overall survival in a selected arm according to molecular response at 1 year from randomization with the reference arm.

Full description

Imatinib at 400 mg daily has emerged as the preferred therapy for newly diagnosed CML patients who do not undergo allogeneic stem cell transplant.

A phase III randomized study, comparing imatinib at 400 mg per day to interferon plus cytarabine in newly diagnosed chronic phase CML patients enrolled 1106 patients from June 2000 to January 2001. 553 patients were randomized to each treatment. For comparative purposes, at 6 months, 75% of patients randomized to imatinib obtained a major cytogenetic response with 51% complete responses. Despite these impressive results, only a minority of patients treated with imatinib in this study achieved a molecular remission. When analyzed by log reduction in Bcr-Abl transcript levels using quantitative RT-PCR, 39% of patients achieved a 3-log reduction in Bcr-Abl levels, but only 13% and 3% achieved a 4- and 5-log reduction, respectively.2 To improve upon these results, various groups have tried higher doses of imatinib, and combinations of imatinib with interferon alpha or cytarabine. Each of these studies has used cytogenetic responses as the major endpoint.

Each of these therapies has increased toxicity as compared to 400 mg of imatinib alone and the rates of molecular remissions have not been reported.

Thus the purpose of this study is to first determine whether higher doses of imatinib or combining Imatinib with interferon or Ara-C would result in higher rates of molecular responses and if so, in better survival.

Enrollment: 789 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients over 18 years of age
• Patients with Bcr-Abl positive CML in chronic phase.
• Patients within 14 weeks of diagnosis and previously untreated for CML except for hydroxyurea and/or anagrelide.
• No evidence of extramedullary leukemic involvement, with the exception of hepatosplenomegaly
• ECOG performance score of 0-2
• acceptable hepatic, renal, and cardiac function
• Informed consent signed up

Exclusion criteria

• Depressive syndrome not controlled
• Uncontrolled medical illnesses.
• Women with childbearing potential and male patients who are unwilling or unable to use an adequate method to avoid pregancy for the entire period of the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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789 participants in 4 patient groups

Imatinib mesylate 400 mg

Experimental group

Treatment:

Drug: Imatinib mesylate 400 mg

Drug: Imatinib 400 mg + Peg-Interferon

Drug: Imatinib mesylate 600 mg

Drug: Imatinib mesylate 400 mg + Cytarabine

Imatinib mesylate 600 mg

Experimental group

Treatment:

Drug: Imatinib mesylate 400 mg

Drug: Imatinib 400 mg + Peg-Interferon

Drug: Imatinib mesylate 600 mg

Drug: Imatinib mesylate 400 mg + Cytarabine

Imatinib mesylate 400 mg +Peg interferon

Experimental group

Treatment:

Drug: Imatinib mesylate 400 mg

Drug: Imatinib 400 mg + Peg-Interferon

Drug: Imatinib mesylate 600 mg

Drug: Imatinib mesylate 400 mg + Cytarabine

Imatinib mesylate 400 mg +Cytarabine

Experimental group

Treatment:

Drug: Imatinib mesylate 400 mg

Drug: Imatinib 400 mg + Peg-Interferon

Drug: Imatinib mesylate 600 mg

Drug: Imatinib mesylate 400 mg + Cytarabine