Sticky Bone and Repeated Injectable PRF (iPRF) Application in Management of Periodontal Intrabony Defects (IPRF)

Al-Azhar University

Status and phase: Unknown; Phase 4

Conditions: iPRF; Periodontal Defect; Sticky Bone

Treatments: Biological: bone substitute; Biological: Sticky Bone and Repeated Injectable PRF (iPRF)

Study type: Interventional

Funder types: Other

Identifiers

NCT05211362

748/2757

Details and patient eligibility

About

One of the main objectives of periodontal therapy is the regeneration of the tooth's supporting periodontal tissue to its original levels. The healing after non-surgical and conventional surgical methods is histologically characterized by a long junctional epithelium along the root surfaces. Therefore, reconstructive techniques are required. Although complete periodontal regeneration is unpredictable with any regenerative therapy currently used, so the objective of our trial is to get complete periodontal regeneration by using Sticky Bone and Repeated Injectable PRF (iPRF) in Management of Periodontal Intrabony Defects.

Enrollment: 32 estimated patients

Sex: All

Ages: 18 to 48 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• No systemic diseases which could influence the outcome of therapy.
• Good compliance with plaque control instructions following initial therapy.
• Teeth involved were all vital with no mobility.
• Each subject contributed a single predominately 2 or 3-wall intrabony interproximal defect around premolar or molar teeth without furcation involvement
• Selected intrabony defects (IBD) measured from the alveolar crest to the defect base in diagnostic periapical radiographs of ≥ 3 mm, the width of ≥ 3 mm at its most coronal part, with no cratering that involve both mesial and distal surfaces of adjacent teeth.
• Selected probing depth (PD) ≥ 6 mm and clinical attachment loss (CAL) ≥ 4 mm at the site of intraosseous defects four weeks following initial cause-related therapy.
• Availability for the follow-up and maintenance program; 8) absence of periodontal treatment during the previous year.

Exclusion criteria

• Pregnant females.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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32 participants in 2 patient groups

Sticky Bone and Repeated Injectable PRF (iPRF)

Experimental group

Description:

The surgical treatment phase was initiated only if the subjects had a full-mouth dental plaque score of less than one and a test site plaque score of 0. Following mucoperiosteal flap reflection for one tooth on either side of the defect, all granulation tissue was removed from the defects by means of Gracey 7/8 metal curettes, and root surfaces were scaled and planed using hand and ultrasonic instruments, then the defect was filled with xenograft mixed with IPRF, Finally, the flap was replaced and closed with crossed horizontal and vertical internal mattress sutures.

Treatment:

Biological: Sticky Bone and Repeated Injectable PRF (iPRF)

bone substitute

Active Comparator group

Description:

The surgical treatment phase was initiated only if the subjects had a full-mouth dental plaque score of less than one and a test site plaque score of 0. Following mucoperiosteal flap reflection for one tooth on either side of the defect, all granulation tissue was removed from the defects by means of Gracey 7/8 metal curettes, and root surfaces were scaled and planed using hand and ultrasonic instruments, bone graft substitute was heavily condensed into the intra bony defects. The flap was replaced and closed with crossed horizontal and vertical internal mattress sutures.

Treatment:

Biological: bone substitute