Stimulant Use and Methylation in HIV

Florida International University (FIU)

Status: Completed

Conditions: Methamphetamine-dependence; HIV Infections; Methamphetamine Abuse

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT05916989

R01DA033854 (U.S. NIH Grant/Contract)

20180865

Details and patient eligibility

About

This study will leverage extracted leukocyte DNA specimens from a completed NIH-funded project to examine the efficacy of a behavioral intervention model that reduced stimulant use on DNA methylation over 6 months.

Enrollment: 53 patients

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• At least 18 years old
• Documentation of HIV-positive serostatus
• Speak English
• Biological verification of recent methamphetamine use
• Completion of at least three contingency management (CM) visits
• Self reported anal sex with a man in the past 12 months

Exclusion criteria

• Inability to provide informed consent, evidenced by cognitive impairment
• HIV negative serostatus

Trial design

53 participants in 1 patient group

Leukocyte DNA Samples

Description:

Leukocyte DNA specimens extracted from participants enrolled in a completed NIH funded trial will be examined to determine if prior exposure to different behavioral interventions modifies DNA methylation patterns over 6 months.