Stochastic Resonance Stimulation Effect on Gait Stability in Parkinson Disease

University of Delaware

Status: Completed

Conditions: Parkinson Disease

Treatments: Device: Stochastic Resonance (SR)

Study type: Interventional

Funder types: Other

Identifiers

NCT06829342

1759595-5

Details and patient eligibility

About

The present study explored the use of a technique called stochastic resonance (SR) stimulation that may help individuals with Parkinson Disease maintain balance while walking on challenging surfaces. Impaired balance represents one of the disease symptoms, putting people at risk for falls, partly due to impaired processing of sensory information. SR uses light electrical signals to improve the way the body detects sensations. We wanted to test if SR could help people with Parkinson disease stay steadier while walking. Each participant's optimal SR intensity was determined before they walked on a treadmill in a virtual environment that created visual disturbances to challenge their balance. We measured how much their body swayed, how they placed their feet, and how their ankles moved during the walking tasks.

Enrollment: 21 patients

Sex: All

Ages: 40 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of Parkinson Disease
• Hoehn and Yahr (H&Y) stage ≤ III
• Can walk independently for at least 2 minutes without an assistive device or orthosis
• Ability to communicate discomfort during testing
• Can follow multi-step commands
• Scored at least 24/30 on the Montreal Cognitive assessment (MoCA)

Exclusion criteria

• Any head, neck, or face injury in the six months prior to the study (e.g., concussion, eye injury)
• History of vestibular or ocular dysfunction
• Currently taking any medications affecting balance (i.e. antibiotics)
• Injuries to lower extremities affecting balance in the past six months
• Pregnancy
• Any neurological disorders other than Parkinson's disease (e.g., seizure disorders, closed head injuries with loss of consciousness greater than 15 minutes, CNS neoplasm, history of stroke)
• Unstable cardiac or pulmonary disease
• Clinically obese (BMI 30 or above)
• Any metal implant in the feet or legs that is close to the stimulating electrodes
• A known allergy to medical-grade adhesives
• Any other comorbidity affecting the ability to safely walk without assistance for at least 2 minutes
• Exhibited severe dyskinesia
• Did not respond to L-DOPA or other dopaminergic treatment
• Exhibited cardiovascular-autonomic or multiple-system symptoms indicative of a "Parkinsonism-plus" presentation

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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21 participants in 2 patient groups

Stochastic Resonance (SR)

Experimental group

Description:

During this condition, participants will walk on the treadmill while receiving SR stimulation at their individual optimal intensity (SR) with and without visual perturbations.

Treatment:

Device: Stochastic Resonance (SR)

No Stochastic Resonance (no-SR)

No Intervention group

Description:

During this condition, participants will walk on the treadmill while receiving no SR stimulation (no-SR) with and without visual perturbations.