Stockholm Myocardial Infarction with Nonobstructive Coronaries Study 3 (SMINC-3)

Karolinska Institute

Status: Enrolling

Conditions: Myocardial Infarction with Nonobstructive Coronary Arteries

Treatments: Diagnostic Test: Cardiac magnetic resonance imaging to study coronary microvascular dysfunction

Study type: Interventional

Funder types: Other

Identifiers

NCT05426408

SMINC-3

Details and patient eligibility

About

The present pilot study will investigate the prevalence of CMD in an unselected cohort of patients with the working diagnosis MINOCA and to study if the diagnostic yield can be improved by adding adenosine to the CMR investigation. Patient will be their own controls.

Enrollment: 85 estimated patients

Sex: All

Ages: 35 to 79 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• a suspected diagnosis of MINOCA or takotsubo syndrome with coronary angiography without diameter stenosis ≥50%
• age 35-80 years
• reading and writing proficiency in Swedish

Exclusion criteria

• Claustrofobia
• Arrythmia and/or pacemaker (atrial fibrillation and AV-block I- III)
• Asthma or severe chronic obstructive lung disease
• eGFR < 30 ml/min
• spontaneous coronary artery dissection
• acute pulmonary embolism
• acute myocardial infarction type 2
• cardiomyopathy other than takotsubo syndrome
• a previous myocardial infarction due to CAD

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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85 participants in 1 patient group

Patients with MINOCA undergoing CMR

Other group

Description:

Patients will be their own controls

Treatment:

Diagnostic Test: Cardiac magnetic resonance imaging to study coronary microvascular dysfunction