Stored RBC Transfusion and Immonomodulation

Università degli Studi di Ferrara

Status: Completed

Conditions: Infections

Treatments: Other: Old RBC; Other: Fresh RBC

Study type: Interventional

Funder types: Other

Identifiers

NCT01976234

04121985

Details and patient eligibility

About

Transfusion of RBC is associated with post operative infections. Our hypothesis is that stored blood could be related with increased post operative infection risk. Surgical patients transfused during the operation or immediately after will be included in our study. Patients will receive fresh or old blood during the whole recovery.

Enrollment: 181 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients transfused during or in 24h after surgical operation

Exclusion criteria

• Patients transfused during the 30 days before the operation
• Immunodepressed patients
• Infections during the 30 days before operations
• Emergency surgery

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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181 participants in 2 patient groups

Fresh group

Active Comparator group

Description:

Fresh group will receive RBC stored for less than 14 days

Treatment:

Other: Fresh RBC

Old group

Active Comparator group

Description:

Old group will receive RBC stored for 14 days or more

Treatment:

Other: Old RBC