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Strategic Ingestion of Creatine Supplementation and Resistance Training in Trained Young Adults

U

University of Regina

Status

Enrolling

Conditions

Muscle
Strength

Treatments

Dietary Supplement: Creatine monohydrate
Dietary Supplement: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT06438887
Bio-REB 4641

Details and patient eligibility

About

Creatine supplementation improves measures of muscle accretion and performance compared to placebo during a resistance training program. However, the optimal creatine supplementation protocol for maximizing these improvements is unknown.

Full description

Creatine is a naturally occurring nitrogen containing compound endogenously produced in the body through reactions involving the amino acids arginine, glycine and methionine. Alternatively, creatine can be consumed in the diet (primarily from red meat and seafood) or through commercially manufactured creatine. It has been proposed that the strategic ingestion of creatine supplementation may be an important factor to consider during a resistance training program to increase muscle growth and performance. There is evidence that creatine supplementation only on training days has greater muscle benefits compared to placebo in healthy older adults. However, the effects of creatine on training days (compared to creatine on non-training days or placebo) in healthy young adults is unknown. Further, pre- and post-exercise creatine supplementation appears to produce similar muscle benefits (compared to placebo) in healthy older adults. It remains to be determined whether the timing of creatine ingestion (immediately before vs. immediately following training sessions) influences the physiological adaptations from resistance training compared to placebo in young healthy adults. It is also unknown whether differences exist in supplementing with creatine immediately before, during or immediately following resistance training sessions in young healthy adults.

Enrollment

52 estimated patients

Sex

All

Ages

18 to 39 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Physically active (performing structured resistance training > 2x/week for ≥ 4 weeks)
  • Males and females (age 18-39)

Exclusion criteria

  • Pregnant or nursing
  • Have consumed creatine monohydrate within 30 days prior to the start of the study
  • Pre-existing allergies to the placebo

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

52 participants in 4 patient groups, including a placebo group

Creatine Before Training
Experimental group
Description:
5 grams of creatine monohydrate + 3 grams of placebo immediately before training sessions; 8 grams of placebo immediately after training sessions; 8 grams of placebo on non-training days.
Treatment:
Dietary Supplement: Placebo
Dietary Supplement: Creatine monohydrate
Creatine After Training
Experimental group
Description:
5 grams of creatine monohydrate + 3 grams of placebo immediately after training sessions; 8 grams of placebo immediately before training sessions; 8 grams of placebo on non-training days.
Treatment:
Dietary Supplement: Placebo
Dietary Supplement: Creatine monohydrate
Creatine Non-Training
Experimental group
Description:
5 grams of creatine monohydrate + 3 grams of placebo on non-training days; 8 grams of placebo immediately before training sessions; 8 grams of placebo immediately after training sessions.
Treatment:
Dietary Supplement: Placebo
Dietary Supplement: Creatine monohydrate
Placebo
Placebo Comparator group
Description:
8 grams of placebo immediately before training sessions; 8 grams of placebo immediately after training sessions; 8 grams of placebo on non-training days
Treatment:
Dietary Supplement: Placebo

Trial contacts and locations

2

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Central trial contact

Darren Candow

Data sourced from clinicaltrials.gov

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