Strategies for Defibrillation During Out-of-Hospital Cardiac Arrest (STRAT-DEFI)

Lars Wiuff Andersen

Status: Enrolling

Conditions: Cardiac Arrest (CA)

Treatments: Other: Anterior-lateral pad positioning; Other: Double-sequential defibrillation; Other: Anterior-posterior pad positioning

Study type: Interventional

Funder types: Other

Identifiers

NCT06781892

00006

Details and patient eligibility

About

The "Strategies for Defibrillation during Out-of-Hospital Cardiac Arrest" (STRAT-DEFI) trial is an investigator-initiated, individually randomized, 3-group clinical trial comparing standard anterior-lateral pad positioning with anterior-posterior positioning and double sequential defibrillation during adult out-of-hospital cardiac arrest.

Enrollment: 909 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Out-of-hospital cardiac arrest
2. Age ≥ 18 years
3. ≥ 1 manual defibrillation attempt by emergency medical services
4. Shockable rhythm as the last known rhythm
5. Two manual defibrillators present on-site

Exclusion criteria

1. Blunt trauma, penetrating trauma, or burn injury suspected to be the cause of the cardiac arrest
2. Prior enrollment in the trial
3. Posterior pad placement not deemed possible by on-site clinician

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

909 participants in 3 patient groups

Anterior-lateral pad positioning

Active Comparator group

Treatment:

Other: Anterior-lateral pad positioning

Anterior-posterior pad positioning

Experimental group

Treatment:

Other: Anterior-posterior pad positioning

Double-sequential defibrillation

Experimental group

Description:

Anterior-lateral pad positioning combined with anterior-posterior pad positioning for a total of 4 pads and 2 shocks.

Treatment:

Other: Double-sequential defibrillation