Strategies to Maintain Radial Artery Patency Following Diagnostic Coronary Angiography - Subgroup of Patients on Oral Anticoagulants (RAPID-2)

University of Luebeck

Status: Unknown

Conditions: Patient Undergoing Diagnostic Coronary Angiography

Treatments: Other: Distal radial access

Study type: Interventional

Funder types: Other

Identifiers

NCT04362020

RAPID-2

Details and patient eligibility

About

To investigate whether omitting systemic anticoagulation during transradial coronary angiography and/or a distal radial access reduce the risk of postprocedural radial artery occlusion

Enrollment: 400 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical indication to perform diagnostic coronary angiography
• Pretreatment with oral anticoagulants (phenprocoumon or direct oral anticoagulants [dabigatran, apixaban, rivaroxaban, or edoxaban])
• Age > 18 years
• Written informed consent

Exclusion criteria

• Already administered additional anticoagulation prior to coronary angiography
• Planned coronary intervention
• Preexisting radial artery occlusion or missing pulse at the potential puncture sites
• Allergy / intolerance to anticoagulants
• Active bleeding or comorbidity with elevated bleeding risk
• Pregnancy
• Inability to sign informed consent
• Participation in another trial

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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400 participants in 2 patient groups

Group-1

Experimental group

Description:

No anticoagulation

Treatment:

Other: Distal radial access

Other: Distal radial access

Group-2

Active Comparator group

Description:

ACT-guided anticoagulation

Treatment:

Other: Distal radial access

Other: Distal radial access