Strategies to Optimize Positive End-expiratory Pressure (PEEP) in Patients With Acute Lung Injury (EIT-PEEP)

University Hospital Bonn (UKB)

Status and phase: Unknown; Phase 2

Conditions: Respiratory Failure; Acute Respiratory Distress Syndrome; Acute Lung Injury

Treatments: Procedure: PEEP titration

Study type: Interventional

Funder types: Other

Identifiers

NCT01326208

EIT-PEEP-2010

Details and patient eligibility

About

The purpose of this study in patients suffering from acute lung injury is to determine whether positive end-expiratory pressure (PEEP) setting guided by electrical impedance tomography (EIT) influences pulmonary gas exchange, lung mechanics, ventilation/perfusion matching and homogeneity of regional ventilation when compared to other PEEP setting strategies such as the open lung concept or the ARDSnet protocol.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• acute lung injury, need for optimization of ventilatory settings

Exclusion criteria

• preexisting chronical lung disease, pneumothorax, pace maker, hemodynamical instability, increased intracranial pressure

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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40 participants in 1 patient group

Acute Lung Injury / ARDS

Experimental group

Description:

Patient under mechanical suffering from ALI or ARDS

Treatment:

Procedure: PEEP titration