Strawberries and Knee Osteoarthritis (OA)

Oklahoma State University

Status: Completed

Conditions: Osteoarthritis, Knee

Treatments: Dietary Supplement: Placebo; Dietary Supplement: FDS-Strawberry

Study type: Interventional

Funder types: Other

Identifiers

NCT02518347

HE1517

Details and patient eligibility

About

The proposed study aims to examine the hypothesis that strawberry supplementation will lower serum biomarkers of inflammation and improve knee function in patients with symptomatic osteoarthritis (OA).

Full description

The investigators propose the following two specific aims in a randomized crossover placebo-controlled trial in participants with two or more features of the metabolic syndrome and symptomatic osteoarthritis in this 12-week efficacy study:

Aim 1: To assess the effects of strawberries on biomarkers of inflammation [serum levels of C-reactive protein: CRP; inflammatory cytokines: interleukin-6: IL-6; interleukin 1β: IL-1β; tumor necrosis factor-alpha: TNFα] Aim 2: To assess the effects of strawberries on knee function as assessed by overall musculoskeletal examination and pain score (ICOAP, KOOS and HAQ-DI).

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of knee osteoarthritis
• Must have waist circumference >35 inches for women and >40 inches for men

Exclusion criteria

• Cancer
• Heart disease
• Smoking
• Berry allergy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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20 participants in 2 patient groups, including a placebo group

FDS-Strawberry

Experimental group

Description:

Freeze-dried strawberry powder (50g/d)

Treatment:

Dietary Supplement: FDS-Strawberry

Placebo

Placebo Comparator group

Description:

Powder matched for carbohydrates and fiber in the strawberries

Treatment:

Dietary Supplement: Placebo