Strength Training and Resveratrol (STaR)

Texas Tech University

Status: Enrolling

Conditions: Anabolic Resistance; Sarcopenia

Treatments: Dietary Supplement: Resveratrol 500 mg oral once daily.; Behavioral: Resistance training; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT06585865

IRB 2024-587 (Other Identifier)

YI-2024-02

Details and patient eligibility

About

The main goal of this study is to find out if supplementing with resveratrol improves skeletal muscle adaptations to strengthening exercise (resistance training or strength training) in adults age 60+, and to determine whether circulating vehicles of inter-organ communication (extracellular vesicles) and their cargo might help explain those responses. The investigators will also examine whether resveratrol supplementation improves blood vessel function and cognitive function (brain health) in response to strength training.

Full description

After screening and providing informed consent, participants (healthy older adults, age 60+, minimally active) will be familiarized with the procedures and undergo pre-testing. After pre-testing, participants will be assigned to supplement with resveratrol or placebo (double-blinded) daily while undergoing a strength training intervention. Strength training will be performed 3x/week for two 6-week blocks, and each visit will be supervised by a member of the study team. An additional week of testing will follow each of the two 6-week blocks.

Enrollment: 36 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 60+
• Minimally active (less than 1 hour of structured exercise/week other than walking)
• No resistance training for the previous 6 months
• Not currently taking resveratrol supplements
• Stable medication, supplement, dietary, and physical activity regimens for the previous 3 months and no plans to change throughout the study period
• Body mass at least 110 lbs

Exclusion criteria

• Medical complications that could increase risk during exercise (e.g., cardiovascular disease, uncontrolled hypertension, type 1 or 2 diabetes, orthopedic contraindication to exercise, kidney disease, etc.)
• Cannabis or nicotine use
• Consume more than 7 alcohol-containing beverages per week

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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36 participants in 2 patient groups, including a placebo group

Resveratrol (RSV) group

Experimental group

Description:

Participants will be randomized to consume resveratrol (500 mg) daily for 14 weeks (two 6-week blocks of resistance training \[supervised, full-body, 3 days/week\] + one testing week \[3 days\] following each block) after the pre-testing period. Participants will be provided with 7 days' worth of supplements at a time in pre-filled pill boxes. Pill boxes will be refilled weekly and adherence monitored.

Treatment:

Behavioral: Resistance training

Dietary Supplement: Resveratrol 500 mg oral once daily.

Placebo

Placebo Comparator group

Description:

Participants will be randomized to consume placebo capsules (cellulose, visually identical to resveratrol capsules) daily for 14 weeks (two 6-week blocks of resistance training \[supervised, full-body, 3 days/week\] + one testing week \[3 days\] following each block) after the pre-testing period. Participants will be provided with 7 days' worth of supplements at a time in pre-filled pill boxes. Pill boxes will be refilled weekly and adherence monitored.

Treatment:

Dietary Supplement: Placebo

Behavioral: Resistance training