Strengthening Tourette Treatment OPtions Using TMS to Improve CBIT, a Double-blind, Randomized, Controlled Study (STOP-TIC)

West Virginia University

Status: Enrolling

Conditions: Tourette Syndrome

Treatments: Device: transcranial magnetic stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT05705999

2211680481

Details and patient eligibility

About

This pilot study will investigate the clinical and neurophysiological effects of repetitive transcranial magnetic stimulation (rTMS) followed by comprehensive behavioral intervention for tics (CBIT) in adult patients with Tourette's Syndrome (TS). Two groups of moderate disease severity will be randomized to receive active or sham rTMS targeted to the supplementary motor area (SMA) followed by eight CBIT sessions. The change in tic frequency and severity (primary outcome) and neurophysiological changes (secondary outcome) will be compared between the two groups. The central hypothesis is that low frequency rTMS will augment the effects of CBIT through favorable priming of the SMA network.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18 years or older
• Diagnosis of Tourette Syndrome
• Moderate Tic Severity at baseline

Exclusion criteria

• Presence of metallic objects or neurostimulators in the brain
• Pregnancy
• History of active seizures or epilepsy
• Contraindications to receiving fMRI
• Inability to participate in CBIT due to other underlying cognitive or medical condition

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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20 participants in 2 patient groups

Active rTMS

Active Comparator group

Description:

Patients receiving active rTMS

Treatment:

Device: transcranial magnetic stimulation

Sham rTMS

Sham Comparator group

Description:

Patients receiving sham rTMS

Treatment:

Device: transcranial magnetic stimulation