Streptococcus Pneumonia: Effects of PCV13 on Pneumococcal Carriage

Boston Medical Center (BMC)

Status: Completed

Conditions: Nasopharyngeal Carriage of S. Pneumoniae

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01109108

H-28757

Details and patient eligibility

About

The specific aim is to evaluate the impact of PCV13 as administered in the pediatric primary care clinic at Boston medical center on the serotype specific carriage of Streptococcus pneumoniae in children < 5.

Specifically the investigators will measure the decline in vaccine serotypes, the proportion of children receiving vaccine required to achieve 50% reduction in serotype specific carriage and the correlation between immunogenicity of the specific serotypes and decline in carriage. The study has been extended to complete 5 years of surveillance to determine the new SP serotype distribution at the time presumably a new equilibrium has been achieved.

Enrollment: 9,000 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• children < 5 years of age receiving care at Primary Care center at BMC and as many parent(s) as willing to participate

Exclusion criteria

• children with facial malformations making NP sampling unacceptable
• children in foster care

Trial design

9,000 participants in 2 patient groups

Children <2 years of age

Description:

Children \<2 years of age with and without respiratory tract infection

Children 2<5 years of age

Description:

Children 2\<5 years of age with and without respiratory tract infection