Stress Adenosine Cardiac Magnetic Resonance (MR) Comparison With Single Photon Emission Computed Tomography (SPECT) Imaging

Sheba Medical Center

Status: Unknown

Conditions: Cardiac Perfusion; Coronary Artery Disease

Treatments: Procedure: Stress Adenosine CMR; Procedure: SPECT Imaging

Study type: Observational

Funder types: Other

Identifiers

NCT00864591

SHEBA-08-5654-OG-CTIL

Details and patient eligibility

About

This study is designed to determine the diagnostic value of adenosine cardiac magnetic resonance (CMR) when compared with SPECT.

The investigators hypothesized that adenosine CMR could detect ischemia and is not inferior to SPECT imaging. In addition stress adenosine cardiac MRI offers a "one stop shop" enabling evaluation of cardiac function, rest and stress perfusion and viability.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Suspected ischemia referred to SPECT stress imaging

Exclusion criteria

• Standard contraindications to MRI including (pacemaker/defibrillator, metallic clips on brain aneurysms, metal fragment in the eye, etc...)
• Congestive heart failure.
• Hemodynamic instability.
• History of asthma or bronchospastic disease.
• Arrhythmia
• Creatinine >1.4
• Non compliant patient, not able to lie supine in the MRI scanner for 1 hour.
• Pregnant patients
• Patients for whom the repeat stress might pose a significant risk.

Trial design

50 participants in 1 patient group

SPECT and stress CMR patients

Description:

patients undergoing SPECT stress imaging, for the evaluation of myocardial ischemia. The study group will include patients with either normal undergoing SPECT stress imaging or with mild to severe ischemia, to include the entire spectrum of coronary artery disease. Patients will be pre selected and evaluated by a non-dependent cardiologist in order to verify that patients in whom the repeat stress might pose a serious risk will be excluded from the study.

Treatment:

Procedure: Stress Adenosine CMR

Procedure: SPECT Imaging