Stress, Diurnal Cortisol, and Breast Cancer Survival

Stanford University

Status: Completed

Conditions: Breast Cancer

Treatments: Drug: Sandostatin

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00226967

IRB-12273

76389 (Other Identifier)

BRSADJ0006 (Other Identifier)

Details and patient eligibility

About

The purpose of this study is to learn about the effects of stress on hormones, the relationship between these hormones and cancer progression.

Full description

The purpose of this study is to investigate stress and tonic activation of diurnal cortisol in aging metastatic breast cancer patients; feedback inhibition & activation of cortisol; and stress-induced phasic activation of cortisol.

Enrollment: 115 estimated patients

Sex: Female

Ages: 35+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Diagnosis of recurrent or metastatic breast cancer.
2. Karnofsky of 70% or greater.
3. Proficient enough in English to be able to take questionnaires and participate in the required tasks.
4. Living within the Greater Bay Area.
5. Age 35 or older .

Exclusion criteria

1. Positive supraclavicular lymph nodes as the only metastatic lesion at the time of initial diagnosis.
2. Active cancers within the past 10 years other than breast cancer, basal cell or squamous cell carcinomas of the skin, or in situ cancer of the cervix.
3. Any other serious medical condition that will effect short term survival
4. History of major psychiatric illness for which patient was hospitalized or medicated, with the exception of depression or anxiety
5. A diagnosis of diabetes.