Stress, EEG, ECG, and Chiropractic (BLI)


Life University






Other: Chiropractic adjustment using an activator

Study type


Funder types




Details and patient eligibility


The Life University Center for Chiropractic Research is conducting a study to better understand the relationship between subjective stress measures and brain patterns during resting state and an auditory oddball task. A secondary aim is to evaluate the impact of a single session of chiropractic care on the resting state and P300 time locked response after a one-week wait period. An additional outcome assessment for this study will be the recording of an electrocardiogram (ECG) of each participant that will be used to analyze their heart rate variability (HRV). Eligible individuals will receive a physical exam to ensure safety during all procedures. They will then sit for a 6-minute resting state EEG and an auditory oddball task. They will complete a series of questionnaires assessing stress. They will receive a chiropractic adjustment using a handheld instrument called an Activator. They will return one week later for a follow-up assessment consisting of the 6-minute resting state EEG, auditory oddball task, and the questionnaires assessing stress.


30 patients




18 to 40 years old


Accepts Healthy Volunteers

Inclusion criteria

  • Individuals between the ages of 18 and 40
  • Individuals who can wear an EEG cap for 40 minutes
  • Individuals who can sit quietly for at least 15 minutes
  • Individuals who have not had a chiropractic adjustment within the last two weeks
  • Individuals who have not received any other interventions, such as osteopathic spinal manipulation, physical therapy rehabilitation or manipulation, massage, body movement therapies or acupuncture within the last 2 weeks.

Exclusion criteria

  • Individuals who have been diagnosed with a serious mental disorder such as schizophrenia or major depressive disorder that could influence EEG results
  • Individuals who do not feel they can sit quietly with limited movement for roughly 15 minutes
  • Individuals who are on psychotropic medications (e.g. Benzodiazepine medications) that influence EEG readings (Benzodiazepine medications include but are not limited to: alprazolam, chlordiazepoxide, clobazam, clonazepam, clorazepate, diazepam, estazolam, flurazepam, lorazepam, midazolam, oxazepam, temazepam, triazolam, etc.)
  • Individuals with any injury or surgery to the skull in the last 6 months, or a history of trauma to the head such as a concussion or stroke
  • Individuals with a hearing impairment (due to the auditory stimulus recording being performed)
  • Individuals who are currently pregnant
  • Individuals with a current litigation related to a physical, health-related injury
  • Individuals with untreated diagnosed osteoporosis or articular instability, such as atlanto-axial instability
  • Individuals with a known heart condition that results in an aberrant ECG recording

Trial design

30 participants in 1 patient group

Experimental group
Individuals under various degrees of stress
Other: Chiropractic adjustment using an activator

Trial contacts and locations



Data sourced from

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