Stress-MRI Assessment After Right Coronary Artery CTO Recanalization

Meshalkin Research Institute of Pathology of Circulation

Status: Completed

Conditions: Coronary Artery Disease; Ischemic Heart Disease; Coronary Atherosclerosis; Coronary Artery Stenosis

Treatments: Procedure: CTO coronary angioplasty; Procedure: Stress-MRI; Drug: Optimal medicamentous treatment

Study type: Interventional

Funder types: NETWORK

Identifiers

NCT02769650

Stress-MRI 1.0

Details and patient eligibility

About

The hypothesis of this study is that Stress-MRI is a clinically significant method of myocardial perfusion assessment after coronary angioplasty with stenting of right coronary artery (RCA) chronic total occlusion (CTO) is performed.

Enrollment: 72 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Stable angina, CCS FC II-IV
• "Right-dominance" coronary circulation according to coronary angiography
• Absence of other significant atherosclerotic coronary lesions (more than 65%)
• High risk of myocardium ischemia according to stress-MRI data (perfusion defect in 2 or more segments in the area of interest)
• Signed, documented informed consent prior to admission to the study

Exclusion criteria

• Acute coronary syndrome
• Contraindications for adenosine stress test
• Low and moderate risk of myocardium ischemia according to stress-MRI data (perfusion defect in less than 2 segments in the area of interest)

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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72 participants in 2 patient groups

Stress-MRI + Chronic total occlusion PCI

Experimental group

Description:

Pre- and postoperative stress-MRI with evaluation of myocardium perfusion defects + Coronary angioplasty with stenting of RCA CTO

Treatment:

Procedure: CTO coronary angioplasty

Procedure: Stress-MRI

Stress-MRI + Optimal medicamentous treatment

Active Comparator group

Description:

Pre- and postoperative stress-MRI with evaluation of myocardium perfusion defects + Optimal medicamentous treatment

Treatment:

Drug: Optimal medicamentous treatment

Procedure: Stress-MRI