Stress Response and Hemodynamic Changes Associated With Intrathecal Anesthesia Versus Caudal Epidural Anesthesia in Infants Undergoing Laparoscopic Inguinal Herniorrhaphy

Tanta University

Status: Completed

Conditions: Laparoscopic Inguinal Herniorrhaphy; Hemodynamic Changes; Stress Response; Infants; Intrathecal Anesthesia; Caudal Epidural Anesthesia

Treatments: Drug: Intrathecal Anesthesia; Drug: Caudal block; Drug: General anesthesia

Study type: Interventional

Funder types: Other

Identifiers

NCT06909396

35680/8/22

Details and patient eligibility

About

The aim of this work was to assess stress response and hemodynamic changes associated with intrathecal anesthesia versus caudal epidural anesthesia in infants undergoing laparoscopic inguinal herniorrhaphy.

Full description

Inguinal hernia repair is the most frequent surgical procedure in early childhood. Various regional anesthetic techniques have been employed to provide optimum intraoperative and postoperative pain control after this procedure.

Introduced decades ago, the use of intrathecal (spinal) anesthesia and caudal block in procedures for different types of laparoscopic abdominal surgery is safe and efficient.

Caudal block is now frequently used in intraoperative and postoperative analgesia for pediatric surgery. In infants and children, central neuraxial block is an important modality for acute postoperative analgesia in addition to combined anesthesia, the goals of postoperative analgesia in children are pain eradication, expedient recovery to daily activities, and prevention of progression of acute postsurgical pain to chronic pain or hyperalgesia

Enrollment: 120 patients

Sex: All

Ages: 1 month to 1 year old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age from full term one month to one year.
• Both sexes.
• Patients with clinical criteria of laparoscopic inguinal herniorrhaphy.

Exclusion criteria

• Refusal of patients' parents.
• Diseases of the central nervous system.
• Patients with metabolic and coagulation defects.
• Pre-term infant.
• Infection at the site of injection.
• Congenital anomaly in vertebral column.
• Patient treated with corticosteroids.
• Patients with respiratory dysfunction.

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 3 patient groups

Control group

Active Comparator group

Description:

Patients received general anesthesia.

Treatment:

Drug: General anesthesia

Intrathecal group

Experimental group

Description:

Patients received intrathecal anesthesia.

Treatment:

Drug: Intrathecal Anesthesia

Caudal block group

Experimental group

Description:

Patients received caudal epidural anesthesia.

Treatment:

Drug: Caudal block