Stress Sensitivity and Reward Responsivity in Depression (CAN-BIND-04)

Dr. Kate Harkness

Status: Completed

Conditions: Depressed

Study type: Observational

Funder types: Other

Identifiers

NCT02798094

PSYC-154-14

Details and patient eligibility

About

The goal of this project is to learn more about the different ways in which people process information that is stressful and rewarding, and how abnormalities in these two processes are related to depression.

Full description

Participants will participate in two 3-hour sessions separated by a week at Providence Care, Mental Health Services, and a third, 1.5-hour session at the Queen's MRI Facility. At the first session participants will complete a packet of questionnaires about their mood and take part in an interview about their mood, medications, drug use, and any other symptoms, as well as an interview about their relationships with their parents and any experiences of abuse. At the second session participants will participate in a stress test, which involves giving a speech to a panel. The investigators will also collect saliva samples to look at stress hormones. Participants will also complete a task on the computer that involves looking at cartoon faces and making decisions about them. At the third session, the investigators take images of of participant's brain using a magnetic resonance scanner.

Participants are invited to participate in a 6-month follow-up for this study, which would involve the same procedure as outline above.

Enrollment: 219 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

For Depressed Participants:

Inclusion Criteria:

• Outpatients aged 18-65
• Currently suffering from unipolar depression
• Fluency in English, sufficient to complete the interviews and self-report questionnaires

Exclusion Criteria:

• Clinical diagnosis of bipolar disorder, psychotic disorders, current alcohol/substance dependence, or significant medical comorbidity
• Treatment-resistant (defined as failing more than 3 trials of anti-depressant medication)
• History of neurological insult (e.g., concussion), neurological disease, seizure disorder
• Smokers
• Pregnant women
• Endocrine disorders
• High suicidal risk, defined by clinician judgement

For Healthy Control Participants:

Inclusion Criteria:

• Adults aged 18-65
• No history of Axis I disorders according to DSM-IV-TR criteria, as determined by the SCID
• No first-degree relatives diagnosed with bipolar disorder
• Fluency in English, sufficient to complete the interviews and self-report questionnaires

Exclusion Criteria:

• History of neurological insult (e.g., concussion), neurological disease, seizure disorder
• Smokers
• Pregnant women
• Endocrine disorders

Trial design

219 participants in 2 patient groups

Depressed Participants

Description:

No intervention

Healthy Control Participants

Description:

No intervention