Strigolactones and Dysplastic Colonic Lesions or Cancer

Clalit Health Services

Status: Unknown

Conditions: Colonic Polyps; Colonic Neoplasms

Treatments: Procedure: biopsy during colonoscopy

Study type: Observational

Funder types: Other

Identifiers

NCT02824835

IDO123

Details and patient eligibility

About

The purpose of this study is to determine the effects of the plant hormones strigolactones, on cell cultures of colonic polyps and colorectal cancer.

Full description

Strigolactones have been shown to anti-proliferative and pro-apoptotic effects in cell cultures of breast and prostate origin, partially by down-regulation of cyclin B1 and induction of cell cycle arrest. In this study the investigators intend to take biopsies from benign colonic polyps and cancer tissue, culture intestinal explants and generate immortalized primary cells as a platform to assess the effect of this plant hormone on cell viability, cell mobility, apoptosis and cytoskeleton modifications.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with positive findings during colonoscopy

Exclusion criteria

• Patients below 18 years old
• Patients who cannot sign a consent form

Trial design

150 participants in 2 patient groups

adenoma group

Description:

Patients with adenoma. Biopsies are taken before endoscopic resection.

Treatment:

Procedure: biopsy during colonoscopy

cancer group

Description:

Patients with colorectal cancer. Biopsies are taken before surgical resection.

Treatment:

Procedure: biopsy during colonoscopy