Stroke Adverse Outcome is Associated With Nosocomial Infections: PCTus- Guided Antibacterial Therapy in Severe Ischemic Stroke Patients (STRAWINSKI)

Charité University Medicine Berlin

Status

Completed

Conditions

Ischemic Stroke

Treatments

Device: Procalcitonin assay - B.R.A.H.M.S PCT ultrasensitive Kryptor

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT01264549

STRAWINSKI

Details and patient eligibility

About

Development of stroke associated pneumonia (SAP) has a detrimental effect on stroke outcome. Biomarker-guided antibiotic treatment of patients at high risk for pneumonia may help to improve stroke outcome. Therefore, the investigators will evaluate whether intensified infection monitoring via Procalcitonin guiding an early standardized antibiotic treatment improves functional outcome after stroke compared with standard therapy based on current guidelines.

Enrollment

230 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

age ≥18 years
stroke onset within the last 40 hours before randomisation
clinical diagnosis of a severe (NIHSS > 9), non-lacunar stroke in the middle cerebral artery territory
consent given by the patient or by his/her legitimate representative where patients are incapable of giving consent themselves

Exclusion criteria

CT evidence of an intracerebral haemorrhage or a lacunar infarct as the probable cause of the current illness
Antibiotic use within the last 10 days
Suspected life expectancy of < 3 months
Participation in other interventional trials (on pharmaceuticals or medical devices)
Pregnancy, lactation
Pre-stroke mRS score ≥ 4