Stroke and Carotid-Cerebral Vascular Disease After CABG (SCCAB)

Shanghai Jiao Tong University

Status: Completed

Conditions: Coronary Artery Bypass

Study type: Observational

Funder types: Other

Identifiers

NCT05036044

KY-2021127

Details and patient eligibility

About

Review the data of patients who underwent coronary artery bypass grafting (CABG) at the Department of Cardiovascular Surgery in Ruijin hospital from March 2020 to May 2022, including medical history, head and neck CTA, head CT scan, and early postoperative (within 7 days after surgery) neurological complications (defined as a composite of stroke, delayed awakening and severe delirium) . Case-control and retrospective cohorts were built to explore risk factors of early postoperative neurological complications, And its association with baseline carotid-cerebral vascular disease.

Describe the epidemiological data of early postoperative neurological complications (stroke, delayed awakening, and severe delirium) after CABG surgery (within 7 days after surgery); explore independent risk factors of compound neurological complications, build predictive models; compare the effects of carotid-cerebral artery disease on early postoperative compound neurological complications.

Enrollment: 1,002 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients who received CABG at the department of cardiac surgery in our hospital.
2. Surgery that patients received includes both isolated and combined CABG surgery.
3. Includes both cardiopulmonary and non-cardiopulmonary bypass.

Exclusion criteria

1. Without complete preoperative examination data, such as carotid-cerebral artery CTA, head CT imaging results and so on.
2. Without complete baseline medical history and 7 day post-surgery record.

Trial design

1,002 participants in 2 patient groups

With moderate or severe carotid-cerebral artery disease

Description:

moderate (stenosis 50-69%) or severe (stenosis 70-100%) carotid-cerebral artery disease

Without moderate or severe carotid-cerebral artery disease

Description:

mild (stenosis 30-49%) or no (stenosis 0-29%) carotid-cerebral artery disease