Stroke Recovery Research Based on EEG-fMRI

Health Science Center of Xi'an Jiaotong University

Status

Completed

Conditions

Motor Neuropathy

Treatments

Diagnostic Test: MRI recording

Diagnostic Test: EEG recording

Study type

Observational

Funder types

Other

Identifiers

NCT05427422

Stroke01

Details and patient eligibility

About

This study is aimed to investigate the post-stroke motor recovery of patients with ischemic stroke based on their neural features extracted from EEG-fMRI data.

Full description

A group of patients with ischemic stroke and age/gender matched healthy controls would be enrolled in this study. Their features of neural activities based on EEG-fMRI fusion scan would be extracted to investigate the mechanisms of motor recovery after stroke. Particularly, the correlations of their features of neural networks or local activities to their motor function (defined as their Fugl-Meyer scores) at enrollment and their recovery time courses consisted of Fugl-Meyer scores in follow-up time points. Data of T1 structural, DSI fiber image and pure EEG (without MRI) would also be collected along with EEG-fMRI fusion data.

Enrollment

147 patients

Sex

All

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age above 18 and below 75 years
Motor impairment in National Institutes of Health Stroke Scale
7-14 days since stroke attack
First-ever ischemic stroke

Exclusion criteria

Motor impairment induced by non-stroke aetiology
Claustrophobia; recognition disorder
History of other severe central nervous system diseases
Any signs unfit for MRI/EEG scan

Trial design

147 participants in 3 patient groups

High Recovery

Description:

Effective recovery rate defined as difference between Fugl-meyer scores in the 6 weeks after stroke onset (eF) and in the enrollment (sF) normalized by (total score-sf) would be used to indicate the recovery Level of a patients, i.e., (eF-sF)/ (total score-sf). A previously reported recovery rate, i.e., proportional recovery((eF-sF)/(total score-sf)=0.7) was chosen as a standard of a high recovery. Patients with effective recovery rate higher than 0.7 at the T1 time point (6 weeks after stroke onset) would be assigned to group with high recovery rate

Treatment:

Diagnostic Test: EEG recording

Diagnostic Test: MRI recording

Low Recovery

Description:

The Low Recovery group indicates that patients with effective recovery rate lower than 0.7

Treatment:

Diagnostic Test: EEG recording

Diagnostic Test: MRI recording

Healthy Control

Description:

Age/sex matched healthy subjects enrolled to compare with group of patients.