Stroke Volume Variation and Pulse Pressure Variation as Predictors of Fluid Responsiveness During Kidney Transplantation

Samsung Medical Center

Status: Completed

Conditions: Kidney Transplantation

Treatments: Procedure: Fluid loading

Study type: Interventional

Funder types: Other

Identifiers

NCT02459470

2013-03-080

2013-03-180 (Other Identifier)

Details and patient eligibility

About

The aim pf this prospective study is to investigate the ability of stroke volume variation (SVV) and pulse pressure variation (PPV) to predict fluid responsiveness in patients undergoing kidney transplantation.

Full description

Optimal intraoperative fluid management guided by central venous pressure (CVP), a traditional intravascular volume status indicator has been established to improve transplanted graft function during renal transplantation. Recently, stroke volume variation (SVV) and pulse pressure variation (PPV), dynamic preload indices derived from the arterial waveform are increasingly advocated as predictors of fluid responsiveness in anesthetized patients and critically ill patients. However, their usefulness in renal failure patients undergoing renal transplantation has not been investigated. Thus, the aims of this study is to investigate accuracy of SVV and PPV for predicting fluid responsiveness in patients undergoing kidney transplantation.

Enrollment: 42 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• chronic renal failure patients undergoing renal transplantation

Exclusion criteria

• patients with cardiac arrhythmia
• patients with reduced left ventricular function (EF < 40%)
• patients with valvular heart disease
• patients intracardiac shunt
• patients with pulmonary hypertension
• patients with extensive peripheral vascular disease
• patients with preoperative use of vasopressors or inotropics

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Single Blind

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42 participants in 1 patient group

SVV and PPV

Experimental group

Description:

SVV(stroke volume variation): recorded using the Flotrac/Vigileo system (Edwards Lifesciences) PPV(pulse pressure variation): recorded using philips Intelivue MP70 monitors (Philips Medical System) Intervention: Other: Fluid loading using HES 130/0.4; voluven; Fresenius Kabi; Stans, Switzerland

Treatment:

Procedure: Fluid loading