Structural and Metabolic Determinants of Sarcopenia and the Efficacy of Concentric vs. Eccentric Exercise Training

University of Nottingham

Status: Completed

Conditions: Healthy

Treatments: Behavioral: Concentric Exercise Training; Behavioral: Eccentric Exercise Training

Study type: Interventional

Funder types: Other

Identifiers

NCT02142855

B13032014 SoMSGEM BBSRC3

Details and patient eligibility

About

The first goal of this study is the follow young and older people over a period of 8 weeks to define the processes responsible for loss of muscle length and width in age-related muscle wasting (sarcopenia) and allow us to look at age-related differences in tendon. Secondly, we will assess two different exercise interventions for reversing human sarcopenia; one which involves shortening of the muscle and the other which involves lengthening, whilst also studying why these exercises work the way they do. This project will have significant implications for our understanding of the control of skeletal muscle and tendon size in humans, particularly in relation to sarcopenia and the surrounding health issues.

Enrollment: 60 patients

Sex: Male

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy male volunteers
• Body mass index 18-30 kg/m2
• Aged 18-35 and 65-75 years

Exclusion criteria

• Participation in a formal exercise regime,
• A BMI < 18 or > 30 kg/m2,
• Active cardiovascular disease,
• Taking beta-adrenergic blocking agents, statins or non-steroidal anti-inflammatory drugs,
• Cerebrovascular disease,
• Respiratory disease,
• Metabolic disease,
• Active inflammatory bowel or renal disease,
• Malignancy,
• Recent steroid treatment (within 6 months) or hormone replacement therapy,
• Clotting dysfunction,
• Musculoskeletal or neurological disorders,
• Family history of early (<55y) death from cardiovascular disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 6 patient groups

Old Control

No Intervention group

Description:

Older individuals (65-75 y) with no exercise intervention

Old Concentric

Experimental group

Description:

Older individuals (65-75 y) studied before and after 8 weeks concentric exercise training

Treatment:

Behavioral: Concentric Exercise Training

Old Eccentric

Experimental group

Description:

Older individuals (65-75 y) studied before and after 8 weeks eccentric exercise training

Treatment:

Behavioral: Eccentric Exercise Training

Young Control

No Intervention group

Description:

Young individuals (18-30 y) with no exercise intervention

Young Concentric

Experimental group

Description:

Young individuals (18-30 y) studied before and after 8 weeks concentric exercise training

Treatment:

Behavioral: Concentric Exercise Training

Young Eccentric

Experimental group

Description:

Young individuals (18-30 y) studied before and after 8 weeks eccentric exercise training

Treatment:

Behavioral: Eccentric Exercise Training