Structural and Molecular Neuroplasticity in Migraine

University of Michigan

Status: Completed

Conditions: Migraine

Treatments: Procedure: Pet Scan; Procedure: MRI scan; Procedure: Quantitative Sensory Testing (QST)

Study type: Interventional

Funder types: Other

Identifiers

NCT03004313

HUM00027383

Details and patient eligibility

About

The main purpose of this study is to integrate novel MRI techniques with positron emission tomography(PET) for the study of structural and molecular neuroplasticity in the brain of migraineurs, and its clinical association with changes in pain perception and modulation (e.g. allodynia). We will attempt to acquire images of the brain that may, in the future, assist doctors in better understanding how pain is felt and regulated in migraine sufferers.

Full description

To investigate interictal opioid receptor (MOR) binding potential (BPND) changes in migraineurs as compared to age/gender-matched healthy controls. To demonstrate that frequency of the headache attacks and severity of cutaneous allodynia levels in migraineurs experienced over multiple attacks are correlated with levels of MOR BPND in specific brain regions. To investigate whether dysfunction of the pain regulatory endogenous opioid system of migraineurs is correlated with changes in the gray matter thickness in cortical areas associated with pain perception and modulation.

Enrollment: 32 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Between 18-45 years of age
• Between 1-14 migraine attacks per month or healthy

Exclusion criteria

• Cannot be taking daily migraine medication
• Healthy subjects cannot be taking hormonal birth control pills or other medication
• Cannot have chronic pain or a neurologic/psychiatric disorder such as: multiple sclerosis and bipolar disorder.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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32 participants in 2 patient groups

Migraine

Experimental group

Description:

20 subjects experiencing 1-14 migraines per month will undergo the following: * Blood and urine samples will be collected * Complete a series of questionnaires; some of which will be completed daily * Quantitative Sensory Test (QST)will be performed * Magnetic Resonance Imaging (MRI) * PET imaging (during and outside of a migraine attack)

Treatment:

Procedure: MRI scan

Procedure: Pet Scan

Procedure: Quantitative Sensory Testing (QST)

Healthy

Active Comparator group

Description:

20 healthy subjects will undergo the following: * Blood and urine samples will be collected * Complete a series of questionnaires; some of which will be completed daily * Quantitative Sensory Test (QST)will be performed * Magnetic Resonance Imaging (MRI) * PET imaging

Treatment:

Procedure: MRI scan

Procedure: Pet Scan

Procedure: Quantitative Sensory Testing (QST)