Structural Cartography of the Insula in Temporal Epilepsy Patients (CON-INSULA)

Central Hospital, Nancy, France

Status: Unknown

Conditions: Epilepsy, Temporal Lobe; MRI Scans

Treatments: Other: MRI

Study type: Observational

Funder types: Other

Identifiers

NCT04871555

2020PI218

Details and patient eligibility

About

The purpose of this study is to investigate insula structural connectivity in temporal epilepsy patients. Insula being at the interface of frontal, parietal, occipital and temporal lobes, its structural organization reflects the brain function. We hypothetize that insular structural organization will be different according to the different subtypes of temporal epilepsy.

Full description

The purpose of this study is to investigate insula structural connectivity in temporal epilepsy patients. Insula being at the interface of frontal, parietal, occipital and temporal lobes, its structural organization reflects the brain function. We hypothetize that insular structural organization will be different according to the different subtypes of temporal epilepsy.

Enrollment: 115 estimated patients

Sex: All

Ages: 15+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• epileptic patients: temporal epilepsy or temporal plus epilepsy (temporomesial epilepsy, basal temporal epilepsy, mesio lateral or lateral epilepsy, temporo insular epilepsy, operculo insular epilepsy)
• patients who underwent video EEG monitoring with recorded seizures (at least one)
• patients who underwent a brain MRI with DTI sequence before epilepsy surgery
• patients who did not refuse the use of their clinical and MRI data for this study

Exclusion criteria

• patients younger than 15 years old
• patients with previous brain surgery (before MRI)
• uncompleted MRI sequences (DTI, T1 anatomical)

Trial design

115 participants in 6 patient groups

mesio-temporal epilepsy

Description:

patients suffering from mesiotemporal epilepsy type

Treatment:

Other: MRI

basal temporal epilepsy

Description:

patients suffering from basal temporal epilepsy type

Treatment:

Other: MRI

temporal lateral epilepsy

Description:

patients suffering from temporal lateral epilepsy type

Treatment:

Other: MRI

operculo insular epilepsy

Description:

patients suffering from operculo insular epilepsy type

Treatment:

Other: MRI

temporo-insular epilepsy

Description:

patients suffering from temporo- insular epilepsy type

Treatment:

Other: MRI

healthy subjects

Description:

non epileptic patients

Treatment:

Other: MRI