Studies Examining the Importance of Smoking After Being Diagnosed With Lung Cancer (LungCast)

Dr Keir Lewis

Status: Completed

Conditions: Lung Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT01192256

09/WMW01/28

WS763986 (Other Grant/Funding Number)

Details and patient eligibility

About

A large project consisting of:

a) an observational trial where smoking status is recorded on 1400 consecutive people newly diagnosed with lung cancer. Smoking status is biologically validated with exhaled carbon monoxide (eCO) levels every 3 months. Survival, cancer progression and treatment complications will be recorded and compared in smokers, ex-smokers and never smokers.

Full description

Smoking causes around 85% of lung cancer. Continued smoking after diagnosis probably worsens survival and increases treatment complications but prospective well-designed studies are lacking.

This project is an observational cohort study recording outcomes in smokers, never-smokers, and ex-smokers, using exhaled carbon monoxide to validate smoking status when they attend for further lung cancer clinics.

This project is unique, as every patient with a clinical diagnosis of lung cancer will have their smoking status biologically validated by a quick and easy test, and those enrolled in the smoking cessation treatments or not will also complete a generic quality of life questionnaire at regular intervals. These appointments will coincide with other hospital appointments wherever possible, and survival status will reported up to 24 months after enrolment.

Enrollment: 2,400 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical diagnosis of lung cancer

Exclusion criteria

• refusal Consent
• inability to provide exhaled CO
• active psychiatric illness or substance misuse
• concurrent malignancies of another type other than non-melanoma skin cancer
• unable to travel for sessions with smoking cessation counsellor and / or outpatient visits from outset
• WHO performance status 4
• Life expectancy less than 6 weeks.