Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in People Living With and Without HIV

National Institute of Allergy and Infectious Diseases (NIAID)

Status: Enrolling

Conditions: Infectious Diseases; HIV; Immunodeficiencies

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00001281

910140

91-I-0140

Details and patient eligibility

About

We are studying virologic and/or immunologic parameters of HIV infection and other infectious or non-infectious immune deficiency diseases in order to better understand the pathogenesis of HIV. Because of the lack of an adequate animal model it is generally necessary to utilize human peripheral blood cells for studying aspects of either in vivo or in vitro HIV infection. We wish to be able to continue to elucidate many pathogenic aspects of HIV infection in relation to other infectious or non-infectious immune regulation and dysregulation using human peripheral blood mononuclear cells as a model....

Full description

We are studying virologic and/or immunologic parameters of HIV infection and other infectious or non-infectious immune deficiency diseases in order to better understand the pathogenesis of HIV. Because of the lack of an adequate animal model it is generally necessary to utilize human peripheral blood cells for studying aspects of either in vivo or in vitro HIV infection. We wish to be able to continue to elucidate many pathogenic aspects of HIV infection in relation to other infectious or non-infectious immune regulation and dysregulation using human peripheral blood mononuclear cells as a model.

Enrollment: 2,419 estimated patients

Sex: All

Ages: 18 to 120 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

• INCLUSION CRITERIA:
• 18 years of age or older.
• Adequate venous access.
• Have a blood pressure less than or equal to 180/100: pulse rate 50-100, unless a lower pulse rate is considered normal for the volunteer.
• Have adequate blood counts (volunteers living with HIV: hemoglobin greater than or equal to 9.0 g/dL, platelets greater than or equal to 50,000; volunteers living without HIV: hemoglobin greater than or equal to 9.0 g/dL, platelets greater than or equal to 50,000
• Be willing and able to provide written informed consent on screening, comply with study requirements and procedures, and comply with clinic policies
• Willingness to allow blood samples to be used for future studies of HIV infection/pathogenesis, and undergo hepatitis screening

EXCLUSION CRITERIA:

• Pregnant and/or breastfeeding females.
• Active substance abuse or history of prior substance abuse that may interfere with protocol compliance or compromise volunteer safety.

Trial design

2,419 participants in 3 patient groups

Individuals living with/without HIV

Description:

Individuals living with/without HIV

Individuals living with/without infectious diseases

Description:

Individuals living with/without infectious diseases of interest

Individuals with/without Immunodeficiencies

Description:

Individuals with/without immunodeficiencies