Study Assessing the Safety and Therapeutic Effect of Buprenorphine in MDD Patients

Shalvata Mental Health Center

Status and phase

Unknown

Phase 1

Conditions

Depression

Treatments

Drug: Buprenorphine

Study type

Interventional

Funder types

Other

Identifiers

NCT01311570

B080910

Details and patient eligibility

About

The primary objective of this study is to assess the therapeutic effect of Buprenorphine in MDD population.

The secondary objectives of this study are to assess the therapeutic effect, the feasibility and safety of buprenorphine in a MDD population.

Enrollment

20 estimated patients

Sex

All

Ages

18 to 68 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Outpatients and inpatients
Men and women 18-68 years of age.
Primary DSM-IV diagnosis of Major Depression, single or recurrent episode confirmed by the Structured Clinical Interview for the DSM-IV (SCID-IV), with the additional requirements of a current episode ≥4 weeks and CGI-S ≥4.
Total HDRS-21 ≥20 and Item 1 score ≥2 at the screening visit.
The patient did not respond to at least one antidepressant medication given for an accepted dose and duration.
If currently taking Benzodiazepines, the patient must be clinically appropriate to discontinue treatment with those agents, and able to tolerate no benzodiazepines during the study period.
Capable and willing to provide informed consent
Able to adhere to the treatment schedule.

Exclusion criteria

Depression secondary to a general medical condition.
History of substance abuse or dependence within the past 6 month (except nicotine and caffeine).
All antidepressant medications, must have been in stable dosage for at least 6 weeks prior to entry into the study, with no anticipation of change over the duration of the study.
Use of any medication(s) listed on the Excluded medication list within the time that mansion for each medication on the list.
Any psychotic disorder (lifetime), including schizoaffective disorder, or major depression with psychotic features • Bipolar disorder • Eating disorder
Presence (within 12 months of baseline) of a personality disorder (such as antisocial, schizotypal, histrionic, borderline, narcissistic) as assessed by the investigator to be primary, causing a higher degree of distress or impairment than MDD.
Use of a Monoamine Oxidase Inhibitor (MAOI) within 2 weeks of the screening visit
Use of a CYP3A4 Inhibitors and CYP3A4 Inducers within 2 weeks of screening visit.
Present suicidal risk as assessed by the investigator or significant suicide risk based on HDRS-21 item 3 score of 3 or 4 or a history of attempted suicide in the last 6 month
Known or suspected pregnancy
Women who are breast-feeding
Women of childbearing potential and not using a medically accepted form of contraception when engaging in sexual intercourse.
Patients with severe respiratory insufficiency or asthma - anticipation require examination of pulmonologist.
Patients with severe hepatic or renal insufficiency.
Patients with history of head injury, increased intracranial pressure, hypotension, prostatic hypertrophy or urethral stenosis- anticipation require examination of neurologist.