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Study " COFLORES "

P

Public Assistance-Hospitals of Marseille (AP-HM)

Status

Completed

Conditions

Myocardial Perfusion

Treatments

Device: sodium-23 MRI
Device: phosphorus-31 Magnetic Resonance Spectroscopy
Device: Magnetic Resonance Imaging (MRI)

Study type

Interventional

Funder types

Other

Identifiers

NCT02848703
2015-45
2016-A00026-45 (Registry Identifier)

Details and patient eligibility

About

Myocardial perfusion is a major parameter characterizing the status of capillary circulation of the myocardium. Its quantification is possible using Magnetic Resonance Imaging (MRI) during the 1st pass of a contrast agent through the capillary system. This technique is radiation-free, but it is difficult to repeat measurements during a single exam. Also, a number of patients suffering from cardiac disease cannot receive contrast agent injections. The investigators have developed a totally non-invasive approach for quantifying myocardial perfusion. It is based on the magnetic labeling of arterial spins. Flowing into the capillaries (Arterial spin labeling, ASL).

Goal : The major goal of this research protocol is to validate a totally non-invasive method of myocardial blood flow quantification using MRI without contrast agent injection

Enrollment

53 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • People having no heart disease or treatment referred to cardiology
  • People having no cons -indications to MRI
  • People having no cons -indications to gadolinium ;
  • People not wearing implantable devices
  • People not wearing metallic foreign bodies or risk (eg . Business of steel, etc .. )
  • People having no cardiovascular risk factor
  • Person subject to the social security scheme
  • Nobody agreeing to participate in the study and who signed the informed consent

Exclusion criteria

  • Refusal to go spontaneous or MRI because of claustrophobia important
  • Trouble rhythm making MRI uninterpretable

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

53 participants in 1 patient group

healthy volunteers
Experimental group
Treatment:
Device: sodium-23 MRI
Device: phosphorus-31 Magnetic Resonance Spectroscopy
Device: Magnetic Resonance Imaging (MRI)

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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